General Cell Based Assays
Abcam BC 11 hydrobromide, Urokinase (uPA) inhibitor, 10MG
MW 290.97 g/mol, Purity >99%. Selective urokinase (uPA) inhibitor (IC₅₀ = 8.2 μM). Shows selectivity over 8 other related enzymes.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Neuraminidase Assay Kit (Fluorometric - Blue)
Neuraminidase Assay Kit (Fluorometric - Blue)
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical 8-ethylthio NAD sodium salt
A derivative of NAD+; has been used in the screening of analog-sensitive PARP1 gatekeeper mutations
Cayman Chemical 8-pCPT NAD sodIum salt 800ug
A derivative of NAD+; has been used in the screening of analog-sensitive PARP1 gatekeeper mutations
Cayman Chemical 8-cPeT NAD sodIum salt 800ug
A derivative of NAD+; has been used in the screening of analog-sensitive PARP1 gatekeeper mutations
Fluotics Bioassay Dish Dividers for Qtray
Bioassay Dish Dividers for Qtray, sterile, 245 x 245 mm2, Case Size: 20 dividers/case, Compare to: X6026
FOCUS BIOMOLECULES Biochemical Reagents, LXG6403, Lysyl oxidase inhibitor, CAS 315705-04-5, 98% by TLC/NMR (Conforms)
Biochemical Reagents, LXG6403, Lysyl oxidase inhibitor, CAS 315705-04-5, 98% by TLC/NMR (Conforms), LXG6403 is a potent (IC50 1.3 uM) and selective (3.5x over LOXL2 and no inhibition of LOX1) lysyl oxidase (LOX) inhibitor. Active against LOX in multiple cell lines (IC50 less than5 uM against MDA-MB-231, HCC143, Hs-578-T, and HCC1937). LXG6403 enhanced chemosensitivity of triple negative breast cancer cells to anthracycline, doxorubicin, cisplatin, and paclitaxel. It inhibited collagen crosslinking and deposition, increased doxorubicin penetration in cells and organoids, inhibited FAK signaling, and potentiated ROS/DNA damage axis in combination with cisplatin. LXG6403 was able to overcome doxorubicin resistance in the TM01278 TNBC PDX model.
Eurofins Discoverx PathHunter TrkC Bioassay Kit, 2-Plate. (93-0464Y3-00077)
The PathHunter TrkC Bioassay Kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This cell line enables assessment of ligand (e.g. NT-3) based activation of TrkC receptors via detection of SH2 domain protein recruitment. The included cell line overexpresses ProLink-tagged TrkC target protein and EA-tagged SH2 domain protein. Upon activation of the receptor by its ligand or an agonist antibody, recruitment of SH2 domain protein to the phosphorylated receptor tail leads to production of EFC signal. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates. For detailed product information, User manual and COA, visit www.discoverx.com/bioassay.
Eurofins Discoverx PathHunter TrkC Bioassay Kit, 10-Plate. (93-0464Y3-00078)
The PathHunter TrkC Bioassay Kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This cell line enables assessment of ligand (e.g. NT-3) based activation of TrkC receptors via detection of SH2 domain protein recruitment. The included cell line overexpresses ProLink-tagged TrkC target protein and EA-tagged SH2 domain protein. Upon activation of the receptor by its ligand or an agonist antibody, recruitment of SH2 domain protein to the phosphorylated receptor tail leads to production of EFC signal. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates. For detailed product information, User manual and COA, visit www.discoverx.com/bioassay.
Eurofins Discoverx PathHunter eXpress TrkA Functional Assay, 2-Plate Kit. (93-0462E3CP16M)
The PathHunter eXpress TrkA Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated TrkA dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses ProLink-tagged TrkA and an EA-tagged SH2 domain protein. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress CCRL2 CHO-K1 β-Arrestin Orphan GPCR Assay, 10-Plate Kit. (93-0333E2ACP1L)
The PathHunter CCRL2 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. CCL19) based activation of CCRL2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CCRL2 and EA-tagged β-Arrestin-2. Activation of CCRL2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress TrkA Functional Assay, 10-Plate Kit. (93-0462E3CP16L)
The PathHunter eXpress TrkA Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated TrkA dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses ProLink-tagged TrkA and an EA-tagged SH2 domain protein. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.